motor skill learning rotarod test Search Results


motor skill motor skill  (Columbus Instruments)
96
Columbus Instruments motor skill motor skill
Motor Skill Motor Skill, supplied by Columbus Instruments, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rotarod motor skills  (Med Associates Inc)
96
Med Associates Inc rotarod motor skills
Rotarod Motor Skills, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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accelerating rotarod  (UGO Basile S.R.L)
90
UGO Basile S.R.L accelerating rotarod
Accelerating Rotarod, supplied by UGO Basile S.R.L, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rotarod apparatus  (Panlab)
90
Panlab rotarod apparatus
( A ) Body weight (in g) at 8–10 weeks of age. CRBN-WT ( n = 24), CRBN-KO ( n = 24), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( B ) Body temperature (in °C) at 8–10 weeks of age. CRBN-WT ( n = 20), CRBN-KO ( n = 20), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Ambulation (total distance travelled, in m) in the open field test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 23), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 21) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Motor performance in the <t>rotarod</t> test (mean time to fall from <t>the</t> <t>apparatus</t> on days 2 plus 3, in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent in the open arms of an elevated plus maze. CRBN-WT ( n = 13), CRBN-KO ( n = 11), Glu-CRBN-WT ( n = 19), Glu-CRBN-KO ( n = 18), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( F ) Time (in s) spent sniffing the cage containing an object (O) or a mouse counterpart (M) in the sociability test. CRBN-WT ( n = 11), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 15) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( G ) Time (in s) spent immobile in the forced swim test. CRBN-WT ( n = 12), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 16) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( H ) Discrimination index values (in %) in the novel object recognition test. CRBN-WT ( n = 12), CRBN-KO ( n = 14), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 15), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 18) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( I ) Ambulation (total distance travelled, in m) in the novel (N) or familiar (F) arm in the Y-maze memory test. CRBN-WT ( n = 26), CRBN-KO ( n = 21), Glu-CRBN-WT ( n = 32), Glu-CRBN-KO ( n = 28), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 23) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( J ) Time (in %) spent freezing in the testing session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .
Rotarod Apparatus, supplied by Panlab, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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accelerating rotarod  (BIOSEB Inc)
90
BIOSEB Inc accelerating rotarod
( A ) Body weight (in g) at 8–10 weeks of age. CRBN-WT ( n = 24), CRBN-KO ( n = 24), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( B ) Body temperature (in °C) at 8–10 weeks of age. CRBN-WT ( n = 20), CRBN-KO ( n = 20), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Ambulation (total distance travelled, in m) in the open field test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 23), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 21) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Motor performance in the <t>rotarod</t> test (mean time to fall from <t>the</t> <t>apparatus</t> on days 2 plus 3, in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent in the open arms of an elevated plus maze. CRBN-WT ( n = 13), CRBN-KO ( n = 11), Glu-CRBN-WT ( n = 19), Glu-CRBN-KO ( n = 18), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( F ) Time (in s) spent sniffing the cage containing an object (O) or a mouse counterpart (M) in the sociability test. CRBN-WT ( n = 11), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 15) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( G ) Time (in s) spent immobile in the forced swim test. CRBN-WT ( n = 12), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 16) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( H ) Discrimination index values (in %) in the novel object recognition test. CRBN-WT ( n = 12), CRBN-KO ( n = 14), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 15), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 18) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( I ) Ambulation (total distance travelled, in m) in the novel (N) or familiar (F) arm in the Y-maze memory test. CRBN-WT ( n = 26), CRBN-KO ( n = 21), Glu-CRBN-WT ( n = 32), Glu-CRBN-KO ( n = 28), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 23) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( J ) Time (in %) spent freezing in the testing session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .
Accelerating Rotarod, supplied by BIOSEB Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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rotarod-5  (San Diego Instruments)
90
San Diego Instruments rotarod-5
( A ) Body weight (in g) at 8–10 weeks of age. CRBN-WT ( n = 24), CRBN-KO ( n = 24), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( B ) Body temperature (in °C) at 8–10 weeks of age. CRBN-WT ( n = 20), CRBN-KO ( n = 20), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Ambulation (total distance travelled, in m) in the open field test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 23), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 21) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Motor performance in the <t>rotarod</t> test (mean time to fall from <t>the</t> <t>apparatus</t> on days 2 plus 3, in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent in the open arms of an elevated plus maze. CRBN-WT ( n = 13), CRBN-KO ( n = 11), Glu-CRBN-WT ( n = 19), Glu-CRBN-KO ( n = 18), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( F ) Time (in s) spent sniffing the cage containing an object (O) or a mouse counterpart (M) in the sociability test. CRBN-WT ( n = 11), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 15) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( G ) Time (in s) spent immobile in the forced swim test. CRBN-WT ( n = 12), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 16) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( H ) Discrimination index values (in %) in the novel object recognition test. CRBN-WT ( n = 12), CRBN-KO ( n = 14), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 15), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 18) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( I ) Ambulation (total distance travelled, in m) in the novel (N) or familiar (F) arm in the Y-maze memory test. CRBN-WT ( n = 26), CRBN-KO ( n = 21), Glu-CRBN-WT ( n = 32), Glu-CRBN-KO ( n = 28), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 23) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( J ) Time (in %) spent freezing in the testing session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .
Rotarod 5, supplied by San Diego Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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motor skill learning rotarod test  (Omnitech Electronics)
93
Omnitech Electronics motor skill learning rotarod test
( A ) Body weight (in g) at 8–10 weeks of age. CRBN-WT ( n = 24), CRBN-KO ( n = 24), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( B ) Body temperature (in °C) at 8–10 weeks of age. CRBN-WT ( n = 20), CRBN-KO ( n = 20), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Ambulation (total distance travelled, in m) in the open field test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 23), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 21) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Motor performance in the <t>rotarod</t> test (mean time to fall from <t>the</t> <t>apparatus</t> on days 2 plus 3, in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent in the open arms of an elevated plus maze. CRBN-WT ( n = 13), CRBN-KO ( n = 11), Glu-CRBN-WT ( n = 19), Glu-CRBN-KO ( n = 18), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( F ) Time (in s) spent sniffing the cage containing an object (O) or a mouse counterpart (M) in the sociability test. CRBN-WT ( n = 11), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 15) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( G ) Time (in s) spent immobile in the forced swim test. CRBN-WT ( n = 12), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 16) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( H ) Discrimination index values (in %) in the novel object recognition test. CRBN-WT ( n = 12), CRBN-KO ( n = 14), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 15), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 18) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( I ) Ambulation (total distance travelled, in m) in the novel (N) or familiar (F) arm in the Y-maze memory test. CRBN-WT ( n = 26), CRBN-KO ( n = 21), Glu-CRBN-WT ( n = 32), Glu-CRBN-KO ( n = 28), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 23) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( J ) Time (in %) spent freezing in the testing session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .
Motor Skill Learning Rotarod Test, supplied by Omnitech Electronics, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A ) Body weight (in g) at 8–10 weeks of age. CRBN-WT ( n = 24), CRBN-KO ( n = 24), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( B ) Body temperature (in °C) at 8–10 weeks of age. CRBN-WT ( n = 20), CRBN-KO ( n = 20), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Ambulation (total distance travelled, in m) in the open field test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 23), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 21) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Motor performance in the rotarod test (mean time to fall from the apparatus on days 2 plus 3, in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent in the open arms of an elevated plus maze. CRBN-WT ( n = 13), CRBN-KO ( n = 11), Glu-CRBN-WT ( n = 19), Glu-CRBN-KO ( n = 18), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( F ) Time (in s) spent sniffing the cage containing an object (O) or a mouse counterpart (M) in the sociability test. CRBN-WT ( n = 11), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 15) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( G ) Time (in s) spent immobile in the forced swim test. CRBN-WT ( n = 12), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 16) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( H ) Discrimination index values (in %) in the novel object recognition test. CRBN-WT ( n = 12), CRBN-KO ( n = 14), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 15), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 18) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( I ) Ambulation (total distance travelled, in m) in the novel (N) or familiar (F) arm in the Y-maze memory test. CRBN-WT ( n = 26), CRBN-KO ( n = 21), Glu-CRBN-WT ( n = 32), Glu-CRBN-KO ( n = 28), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 23) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( J ) Time (in %) spent freezing in the testing session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .

Journal: EMBO Molecular Medicine

Article Title: The CB 1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls

doi: 10.1038/s44321-024-00054-w

Figure Lengend Snippet: ( A ) Body weight (in g) at 8–10 weeks of age. CRBN-WT ( n = 24), CRBN-KO ( n = 24), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( B ) Body temperature (in °C) at 8–10 weeks of age. CRBN-WT ( n = 20), CRBN-KO ( n = 20), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Ambulation (total distance travelled, in m) in the open field test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 23), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 21) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Motor performance in the rotarod test (mean time to fall from the apparatus on days 2 plus 3, in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent in the open arms of an elevated plus maze. CRBN-WT ( n = 13), CRBN-KO ( n = 11), Glu-CRBN-WT ( n = 19), Glu-CRBN-KO ( n = 18), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 20) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( F ) Time (in s) spent sniffing the cage containing an object (O) or a mouse counterpart (M) in the sociability test. CRBN-WT ( n = 11), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 15) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( G ) Time (in s) spent immobile in the forced swim test. CRBN-WT ( n = 12), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 22), Glu-CRBN-KO ( n = 20), GABA-CRBN-WT ( n = 11), GABA-CRBN-KO ( n = 16) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( H ) Discrimination index values (in %) in the novel object recognition test. CRBN-WT ( n = 12), CRBN-KO ( n = 14), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 15), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 18) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( I ) Ambulation (total distance travelled, in m) in the novel (N) or familiar (F) arm in the Y-maze memory test. CRBN-WT ( n = 26), CRBN-KO ( n = 21), Glu-CRBN-WT ( n = 32), Glu-CRBN-KO ( n = 28), GABA-CRBN-WT ( n = 20), GABA-CRBN-KO ( n = 23) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( J ) Time (in %) spent freezing in the testing session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .

Article Snippet: To assess motor learning skills, the mouse was placed in a rotarod apparatus (Panlab #LE8205) at a constant speed (4 rpm), which was then accelerated (4 to 40 rpm in 300 s) once the animal was put in place.

Techniques: Two Tailed Test

( A ) Motor learning in the rotarod test (mean time to fall from the apparatus on day 1, 2 or 3; in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( B ) Stride length (in cm) in the footprint test. CRBN-WT (n = 13), CRBN-KO ( n = 8), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 13), GABA-CRBN-WT ( n = 9), GABA-CRBN-KO ( n = 11) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Entries in the central part of an open field arena (normalized to total ambulation). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 19), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Time to show pain symptoms (in s) in the hot plate test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 19), GABA-CRBN-WT ( n = 21), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent freezing in the conditioning session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .

Journal: EMBO Molecular Medicine

Article Title: The CB 1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls

doi: 10.1038/s44321-024-00054-w

Figure Lengend Snippet: ( A ) Motor learning in the rotarod test (mean time to fall from the apparatus on day 1, 2 or 3; in s). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 24), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by two-way ANOVA with Sidak’s post hoc test. ( B ) Stride length (in cm) in the footprint test. CRBN-WT (n = 13), CRBN-KO ( n = 8), Glu-CRBN-WT ( n = 17), Glu-CRBN-KO ( n = 13), GABA-CRBN-WT ( n = 9), GABA-CRBN-KO ( n = 11) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( C ) Entries in the central part of an open field arena (normalized to total ambulation). CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 19), GABA-CRBN-WT ( n = 19), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( D ) Time to show pain symptoms (in s) in the hot plate test. CRBN-WT ( n = 18), CRBN-KO ( n = 15), Glu-CRBN-WT ( n = 20), Glu-CRBN-KO ( n = 19), GABA-CRBN-WT ( n = 21), GABA-CRBN-KO ( n = 24) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. ( E ) Time (in %) spent freezing in the conditioning session of the fear conditioning protocol. CRBN-WT ( n = 10), CRBN-KO ( n = 10), Glu-CRBN-WT ( n = 24), Glu-CRBN-KO ( n = 24), GABA-CRBN-WT ( n = 13), GABA-CRBN-KO ( n = 14) mice (mean ± SEM). Circles, male mice; triangles, female mice. p values were obtained by unpaired two-tailed Student’s t test. .

Article Snippet: To assess motor learning skills, the mouse was placed in a rotarod apparatus (Panlab #LE8205) at a constant speed (4 rpm), which was then accelerated (4 to 40 rpm in 300 s) once the animal was put in place.

Techniques: Two Tailed Test, Hot Plate Test